SOME EYE PROBLEMS IN TIBETAN TERRIERS

Cataracts in Tibetan Terriers are basically the same as in humans - the bluish white thickening that you can (eventually) see for yourself, though identifiable at a much earlier stage by a canine ophthalmologist.  Some cataract development is normal, as part of the aging process.  However, there is also a cataract which may occur in a much younger dog (as young as two or three or possibly earlier).  These cataracts are considered hereditary.  Whether to remove them or not is determined on a case-by-case basis as far as I know, with not removing them the more common practice as the dog doesn't usually benefit long-term. 

Please click here for more indebt information on Cataracts, and also here  for yet another article.

Progressive Retinal Atrophy is where the retina of the eye gradually disintegrates.  First the dog will lose his "night vision" and then it will progress to 24 hour blindness as well.  This also is hereditary.  There is no cure and no treatment.  There seems to be two "varieties" of PRA - one that is evident by the time the dog is a couple of years old and one which is a very late onset (and might be missed by the average owner, or even vet, thinking the dog is just losing his/her vision due to old age).  It is hereditary - so far as is known, both parents must be carriers (i.e., both may themselves appear to be fine but carry the genes which "pair up"). 

Please click here for PRA Diagnosis and click here for Screening for Progressive Retinal Atrophy in Tibetan Terriers.

Lens Luxation is where the lens of the eye becomes detached.  The way my ophthalmologist described it (for the dog) is it probably feels like a contact lens, which has become dislodged - extremely uncomfortable and painful.  The "cure" is to remove the lens surgically in an operation that is not unlike cataract surgery though even more delicate.  It also occurs bilaterally - meaning that when one lens goes, the other one will soon follow suit.  The dog looses the ability to switch from "close up" to "long distance" vision - he'll be able to see things up close but not in the distance.  Depending on where the lens fell to, there may also be a resultant secondary glaucoma - which requires eye drops daily for the rest of the dog's life.  Lens Luxation is tricky - it does not occur before the age of three years (which is why I rarely breed my dogs before the age of three) and may occur as late as seven, eight, or nine year old, when a dog may have already produced/sired litters (which is one reason why I like people who buy my pups to keep in touch with me over the years).  Lens Luxation is hereditary.

Please click
here for more indebt information on Lens Luxation, and also here for yet another article.
 
The major project at this time that researchers are working on is to find the "marker gene" - i.e. the piece of the DNA that gives the cells the "instructions" to grow in a particular way - for both PRA and Lens Luxation.  Eventually, the idea is that we will be able to draw a blood or tissue sample from a dog before it is bred and see if it carries the DNA "coding" to create PRA or Lens Luxation.  We then can avoid breeding dogs who have these genes and therefore not produce pups with these defects (this is the ideal scenario), or at least avoid breeding two together that both have the piece of genetic coding to potentially match up so that the worst that we would produce would be potential carriers (then all the offspring would have to be tested as well for the next generation).  While the ideal is to eliminate the problem, sometimes the "bad" gene can be tied to something desirable that you would loose along with the undesirable and sometimes there just aren't enough good quality dogs to select from if you eliminate all the carriers. Until this comes into practice in Ireland, all we have to rely on are annual eye tests by a qualified Ophthalmologist. 
Important update see News 2006 30th May.

To facilitate breeders in Ireland, I am happy to organise an Eye Testing Clinic every year.  This clinic is conducted by Dr. T. D. Grimes BVetMed PhD DVR DVOpthal DECVO MRCVS.  I arrange for  this clinic to be held at The National Show Centre in Cloghran, as it is considered by most to be an easy venue to reach, and is known to all but the novice breeders.  I promote the testing with a mailing shot well in advance of the date it is to be held, advertise it at shows and training centres, and also make it easy for some, by giving them the opportunity to book on line at this site.  I cannot stress strongly enough the IMPORTANCE OF ANNUAL EYES TESTS if you plan to breed.

PLL Testing

Congratulations to Dr Cathryn Mellersh & her team at the Animal Health Trust on successfully identifying the mutation for Primary Lens Luxation & for the development of a screening test.  A DNA test to determine a dog’s genotype with respect to Primary Lens Luxation (PLL) is now available.

Testing kits can be requested by e-mail from swab.request@aht.org.uk.
If you do not have access to email you can telephone:
 0044 (0)1638 555621      or fax       0044 (0) 1638 555666

When buying a Tibetan Terrier  I strongly suggest buying from a breeder that can produce Certificates
 for DNA screening of PLL and NCL, Certificates for the yearly BVA eye test, and also Certificate of Hip Score.

PLL Genetic Testing
02.11.2009

Joint statement by the Tibetan Terrier Association and The Tibetan Terrier Breeders & Owners Club regarding the genetic test for Primary Lens Luxation and it’s implication for breeding. 

We strongly recommend that all breeding stock has a known genetic status for Primary Lens Luxation.  This can be determined by a DNA test offered by the Animal Health Trust or as a consequence of knowing both parents are genetically clear. 

The test can be obtained privately from the Animal Health Trust and taken to your vet where the permanent identification is then verified by their signature, or through clinics run by the Tibetan Terrier clubs.

Dogs which are carriers will not develop the condition.  No tested carrier TT’s have yet gone on to develop PLL.  It is essential that carriers are ONLY mated to genetically clear dogs.  As the offspring have the potential to be carriers we advise that the litter be tested prior to sale, and wherever possible only the clears should be used in future breeding.  It is hoped that no second generation carriers will be bred from.  We recommend that the genetic status of any puppies sold is fully explained to new owners.  Carrier puppies should be sold with breeding endorsement ‘Progeny Not Eligible For Registration’.  This endorsement should be fully explained to potential owner and a signature of acceptance obtained. 

 PLL Testing Kits

Testing kits are now available from the Animal Health Trust. 

Please contact either the Animal Heath Trust       dnatesting@aht.org.uk
Or TTA Chairman Mrs. Pat Tempest 
                     ttachairman@aol.com

Animal Health Trust Link

 

New DNA Genetic Testing Scheme for NCL
31.01.2011

At the request of the Tibetan Terrier Clubs in England, the Kennel Club (U.K.) has recently approved a new official DNA testing scheme for Neuronal Ceriod Lipofuscinosis (NCL).  The test is offered by the Orthopaedic Foundation for Animals (OFA) in America and further details can be obtained from them at www.offa.org/dnatesting/ncl.html

What is NCL?

Canine Ceroid Lipofuscinosis is an inherited neurological disorder affecting Tibetan Terriers for which there is no known cure.  It is a multi-systemic storage disease thought to be caused by an inborn error of metabolism. This metabolic error results in the accumulation of storage bodies thought to affect the ability of nerve cells to function.  CCL (NCL) in Tibetan Terrier has been characterized by manifestation of at least some of the following symptoms and diagnostic observations:

- decrease in or loss of vision, particularly in dim light, changes in dark adaptation
- ataxia, a loss of normal muscular co-ordination and movement, often associated with an irregular gait,
  loss of balance, and a roaching of the back
- a progressive Alzheimer-like dementia, which can include difficulty adapting to changes in
  environment, confusion, aggressive behaviour
- seizures in the advanced stages of the disease

 


 

 

 

 

 

 

 

© Siddhartha Tibetan Terriers Ireland