Congratulations to Dr Cathryn Mellersh & her team at
the Animal Health Trust on successfully identifying the mutation
for Primary Lens Luxation & for the development of a screening test. A DNA test to
determine a dog’s genotype with respect to Primary Lens Luxation (PLL)
is now available.
Testing kits can be requested by e-mail from
swab.request@aht.org.uk.
If you do not have access
to email you can telephone:
0044 (0)1638 555621 or fax 0044 (0) 1638
555666
When buying a Tibetan Terrier I strongly suggest
buying from a breeder that can produce
Certificates
for DNA screening of PLL
and NCL, Certificates for the yearly BVA
eye test,
and also Certificate of Hip Score.
PLL Genetic Testing
02.11.2009
Joint statement by the Tibetan Terrier Association
and The Tibetan Terrier Breeders & Owners Club regarding the genetic
test for Primary Lens Luxation and it’s implication for breeding.
We strongly recommend that all breeding stock has a
known genetic status for Primary Lens Luxation. This
can be determined by a DNA test offered by the Animal Health Trust or as
a consequence of knowing both parents are genetically clear.
The test can be obtained privately from the Animal
Health Trust and taken to your vet where the permanent identification is
then verified by their signature, or through clinics run by the Tibetan
Terrier clubs.
Dogs which are carriers will not develop the
condition. No tested carrier TT’s have yet gone on to
develop PLL. It is essential that carriers are
ONLY mated to genetically clear dogs. As the offspring have
the potential to be carriers we advise that the litter be tested prior
to sale, and wherever possible only the clears should be used in future
breeding. It is hoped that no second generation
carriers will be bred from. We recommend that the
genetic status of any puppies sold is fully explained to new owners.
Carrier puppies should be sold with breeding endorsement ‘Progeny
Not Eligible For Registration’. This endorsement
should be fully explained to potential owner and a signature of
acceptance obtained.
PLL
Testing Kits
Testing kits are now available from the Animal
Health Trust.
Please contact either the Animal Heath Trust
dnatesting@aht.org.uk
Or TTA Chairman Mrs. Pat Tempest
ttachairman@aol.com
Animal Health Trust Link

New DNA Genetic Testing Scheme for NCL
31.01.2011
At the
request of the Tibetan Terrier Clubs in England, the Kennel Club (U.K.)
has recently approved a new official DNA testing scheme for Neuronal
Ceriod Lipofuscinosis (NCL). The test is offered by the
Orthopaedic Foundation for Animals (OFA) in America and further details
can be obtained from them at
www.offa.org/dnatesting/ncl.html
What is NCL?
Canine Ceroid Lipofuscinosis is an inherited neurological disorder
affecting Tibetan Terriers for which there is no known cure. It is
a multi-systemic storage disease thought to be caused by an inborn error
of metabolism. This metabolic error results in the accumulation of
storage bodies thought to affect the ability of nerve cells to function.
CCL (NCL) in Tibetan Terrier has been characterized by manifestation of
at least some of the following symptoms and diagnostic observations:
- decrease in or loss of vision, particularly in dim light, changes in
dark adaptation
- ataxia, a loss of normal muscular co-ordination and movement, often
associated with an irregular gait,
loss of balance, and a roaching of the back
- a progressive Alzheimer-like dementia, which can include difficulty
adapting to changes in
environment, confusion, aggressive behaviour
- seizures in the advanced stages of the disease